Acetaminophen overdose symptoms reddit

Paracetamol overdose. However convincing the numerous reports of liver damage following paracetamol overdosage in chronic alcoholics may be [2–20], they are purely anecdotal and the inescapable fact remains that exactly the same severe and fatal liver damage occurs after overdosage in patients who are not chronic alcoholics.The …

Acetaminophen overdose symptoms reddit. acute overdose or during repeated overdose. Acute acetaminophen overdose is defined as an ingestion of a toxic amount of acetaminophen occurring within a period of 8 hours or less. In adults and adolescents, hepatotoxicity may occur following ingestion of greater than 7.5 to 10 grams (g) (eg, 24 regular-strength or 15

The extra acetaminophen spills over into a back-up pathway in the liver, and the liver breaks the excess down into another product that is toxic to it. The more acetaminophen taken at one time, the more toxic product is made. In the first 24 hours after an overdose, there may only be mild symptoms such as nausea and vomiting, but many have no ...

Key takeaways: Acetaminophen (Tylenol) is one of the most commonly used medications, so it’s worth knowing the risks of combining it with alcohol. Mixing acetaminophen and alcohol can potentially lead to liver damage. Rarely, liver damage can be severe or even life-threatening. Moderation is key.Whatever the reason underlying the overdose, excessive amounts of acetaminophen have the potential to be medically dangerous and can result in acute liver failure. Acute liver failure can be fatal ...Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose. Diarrhea increased sweating loss of appetite nausea or vomiting stomach cramps or pain swelling, pain, or tenderness in the upper abdomen or stomach area Other side effects not listed may also occur in some patients.An overdose of Acetaminophen can cause acute liver failure, which is a highly unpleasant event to go through. It is associated with cerebral edema ( swelling of the brain) and blood clots and other nasty complications and can lead to the need for a liver transplant or to death. Tylenol within labeled limits is safe for most people.That's the defining characteristic of a tylenol OD--it is completely asymptomatic in its initial stages. If you're taking >4,000 mg of acetaminophen a day, you risk irreversible liver damage. The first symptoms will be feeling tired and achy, like you have the flu. Dextromethorphan is a drug used in many over-the-counter cough and cold medicines for its antitussive effects.[1] It comes in oral strips, lozenges, liquids, or liquid-filled capsules and formulations often combine the drug with guaifenesin, acetaminophen, and pseudoephedrine.[1] Dextromethorphan is also a commonly abused drug because of its …acute overdose or during repeated overdose. Acute acetaminophen overdose is defined as an ingestion of a toxic amount of acetaminophen occurring within a period of 8 hours or less. In adults and adolescents, hepatotoxicity may occur following ingestion of greater than 7.5 to 10 grams (g) (eg, 24 regular-strength or 15Paracetamol poisoning, also known as acetaminophen poisoning, is caused by excessive use of the medication paracetamol (acetaminophen). [2] Most people have few or non-specific symptoms in the first 24 hours following overdose. These symptoms include feeling tired, abdominal pain, or nausea. This is typically followed by absence of symptoms for ...

Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. ... Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal ...Acetaminophen Poisoning. Acetaminophen, a common ingredient in many prescription and non-prescription drugs, is safe in normal doses, but severe overdose can cause liver failure and death. People sometimes ingest too many products that contain acetaminophen and poison themselves. Depending on the amount of acetaminophen in the blood, symptoms ...at these dosages its highly unlikely to some kind of overdose BUT i dont know what your kidney or liver function was prior to this. it seems much more possible and probable you could have developed a stomach ulcer. bring it up to your dr and maybe ask to check your kidney and liver function with a blood test and if those come back fine theyll probably pursue testing to see if its an ulcer ...However, a larger overdose, especially in children or older adults, may cause serious symptoms. Toxic doses of antihistamines may happen when a person takes 3 to 5 times the normal amount .Have you ever taken too much acetaminophen? (5000+) : r/opiates I took 5325 mg of acetaminophen almost 72 hrs ago. It was reckless not to do a CWE but I usually don't do hydro so I thought I'd screw it up anyway… Coins 0 coins Premium Powerups Explore GamingSymptoms of acetaminophen overdose may take many days to appear, and even when they become apparent, they may mimic flu or cold symptoms. The current maximum recommended adult dose of ... Many diseases and conditions list pain as a component of their presentation; as a result, pain management is of great importance to clinicians and patients alike. Acetaminophen (APAP - also known as paracetamol in many countries) is a non-opioid analgesic and antipyretic agent used to treat pain and fever. It is used as a single agent for mild to moderate pain and combined with an opioid ...

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal. The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your …A Vyvanse overdose may lead to cardiac events, as well as sudden death. Symptoms and signs of Vyvanse overdose can also include: 1,3. Uncontrollable shaking. Seeing or hearing things that are not there ( hallucinations ). Feelings of panic. Aggressive behaviors. Nausea and vomiting. Confusion and disorientation. Fever.Toxicity. Drugs may have toxic effects due to various reasons. Toxicity of some drugs is related to the formation of an undesirable metabolite; consequently, toxicity of acetaminophen is related to the production of NAPQI. With large acute doses or with chronic use, the major metabolic pathways—the glucuronide and sulfate conjugation …Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. ... Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal ...Acetaminophen overdose. Taking too much acetaminophen (Tylenol, others) is the most common cause of acute liver failure in the United States. Outside of the United States, acetaminophen is known as paracetamol. Acute liver failure can occur after one very large dose of acetaminophen, or after higher than recommended doses every day for several ...

Iraq dinar news hound.

Follow the Directions. Read the label on your medication. Don’t take more than directed, even if you’re still in pain or don't feel well. Even when you stick to the recommended dose, you ...Aug 24, 2023 · "In general, the most acetaminophen adults can safely take is 4,000 milligrams or 4 grams in a 24-hour period,” says Grassi. To help keep track of how much you’re taking, set a reminder in your phone or on your voice assistant. Symptoms of an acetaminophen overdose. About one-third of acetaminophen overdoses in the U.S. are accidental. Aug 23, 2007 · Here in Colorado, the Rocky Mountain Poison Center received 835 calls in 2006 for acetaminophen overdose in children 5 and under, according to Mary Hilko, public education coordinator. In the U.S ... 03‏/08‏/2022 ... Percocet is a prescription medication that contains the narcotic pain reliever oxycodone and the non-narcotic pain reliever acetaminophen. It is ...Likewise, the higher the dose, the greater the likelihood of damage. Moreover, this liver injury from an overdose of acetaminophen is a serious matter because the damage can be severe and result in liver failure and death. Acetaminophen overdose is the leading cause of acute (rapid onset) liver failure in the U.S. and the United Kingdom.Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen: Symptoms of overdose. Diarrhea; increased sweating; loss of appetite; nausea or vomiting; stomach cramps or pain; swelling, pain, or tenderness in the upper abdomen or stomach area; For Healthcare Professionals

But as a constant stream of mixed medication. That's simply stupid. Short-term studies of therapeutic doses of acetaminophen in abstinent alcoholics have not demonstrated hepatotoxicity. So there's that. Many patients with non-intentional acetaminophen overdose report short-term fasting and/or poor nutritional status immediately preceding the ...Supportive care. Not much else to do unless she needs a liver transplant but as a result of 15 Tylenol? I'm not a toxicologist but I feel like you gotta ingest more than that to bring your liver offline. littlebrotherpunk • 9 yr. ago Not sure. My big concern was with how long it was in her system and her body weightSymptoms of acetaminophen (Tylenol) poisoning may include. nausea, vomiting, feeling unwell (malaise), not being able to eat or having a poor appetite, yellow eyes, and. skin, or abdominal pain. Acetaminophen overdose can damage the liver. In severe cases, a liver transplant may be necessary.Acetaminophen is one of the most commonly taken medications in the United States, with an estimated 52 million consumers — 23% of adults in the country — using medications that contain this pain reliever each week, according to the Consumer...Some cats will develop fluid buildup in the face, paws, and forelimbs several hours after ingesting acetaminophen. The urine may become dark or even chocolate-colored from the presence of blood or methemoglobin. Occasionally, the first sign of acetaminophen toxicity is death. Death as a result of methemoglobinemia occurs …Poisoning is a serious worldwide public health problem. Based on WHO data in 2012, almost 190,000 people died worldwide and the number of deaths due to poisoning in 2008 exceeded the number of deaths due to motor vehicular crashes; also, poisoning death rate nearly tripled worldwide. Number of patients presenting to the emergency …Aug 29, 2023 · It is possible to experience acetaminophen poisoning in the form of severe liver damage when too much of the drug has been consumed. Whether intentionally or accidentally, acetaminophen overdose requires immediate medical attention to prevent further damage to the body. Symptoms of liver damage include: Yellowing of skin or eyes. Pain in abdomen. An ibuprofen addiction can put you at risk for an overdose and other serious health conditions, including heart attack, stroke, kidney damage, and liver damage. Ibuprofen is a medication classified as a nonsteroidal anti-inflammatory drug (NSAID). People take ibuprofen for fevers, headaches, body pain, stiffness, and swelling.Depending on the amount of acetaminophen in the blood, symptoms range from none at all to vomiting and abdominal pain to liver failure and death. The diagnosis ...Acetaminophen is one of the most commonly taken medications in the United States, with an estimated 52 million consumers — 23% of adults in the country — using medications that contain this pain reliever each week, according to the Consumer...So I was wondering today why the max dose of codeine is often quoted as 240mg. I have tried to find a reason but the papers see to refer to each other or to a cochrane review where all they really say is that 240mg is the usual max dose. I thought someone here might know the answer but I was also hoping someone here would be able to direct me ...

No. The liver damage only occurs when the normal metabolic pathways for acetaminophen are overloaded or somehow damaged. The drug can be cleared by …

Advertising on Reddit can be a great way to reach a large, engaged audience. With millions of active users and page views per month, Reddit is one of the more popular websites for discussions online. It’s also an incredibly powerful platfor...Diagnosis. Treatment. Acetaminophen poisoning can cause gastroenteritis within hours and hepatotoxicity 1 to 3 days after ingestion. Severity of hepatotoxicity after a single acute overdose is predicted by serum acetaminophen levels. Treatment is with N - acetylcysteine to prevent or minimize hepatotoxicity.Taking too much acetaminophen can be deadly because it can lead to hepatotoxicity (liver toxicity). Because Tylenol is available over the counter, acetaminophen overdose is one of the most common types of overdose around the world today. The liver is responsible for converting and clearing many chemicals from the body, including drugs like ...Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine. Daily alcohol use, especially when combined with acetaminophen, may …The most common symptom of a diazepam overdose is falling into a deep sleep or "coma" while still being able to breathe well enough. Other symptoms may include: Bluish-colored lips and fingernails. Blurred vision , double vision. Breathing is slow, labored, or stopped. Confusion.Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. ... Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal ...May 21, 2023 · pain in the lower back and/or side (severe and/or sharp) pinpoint red spots on the skin. skin rash, hives, or itching. sore throat (not present before treatment and not caused by the condition being treated) sores, ulcers, or white spots on the lips or in the mouth. sudden decrease in the amount of urine. unusual bleeding or bruising. DESCRIPTION. Acetylcysteine injection is an intravenous antidote for the treatment of acetaminophen overdose. Acetylcysteine is the nonproprietary name for the N-acetyl derivative of the naturally occurring amino acid, L-cysteine (N-acetyl-L-cysteine).The compound is a white crystalline powder, which melts in the range of 104° …

Moores funeral home ga.

Aerotek employment verification.

Jan 2, 2023 · Symptoms of a hydrocodone and acetaminophen overdose include: Bluish-colored fingernails and lips (cyanosis) Breathing problems, including slow and labored breathing, shallow breathing, or no breathing. Cold, clammy skin. Decreased level of consciousness and lack of responsiveness. Loss of consciousness, coma. Acetaminophen (one form of which is called Tylenol®) poisoning is by far the leading single cause of ALF in the US and is responsible for nearly 50% of all cases. Acetaminophen is an intrinsic, dose-dependent liver toxin, which means that if any given individual takes enough acetaminophen, they will develop severe liver injury, possible ...The most common symptom of a diazepam overdose is falling into a deep sleep or "coma" while still being able to breathe well enough. Other symptoms may include: Bluish-colored lips and fingernails. Blurred vision , double vision. Breathing is slow, labored, or stopped. Confusion.Sorry if the formatting is bad, I dont often post big stories on reddit. Also throw away accounts are silly Overdosing on pills isnt easy in the slightest, last year at around this time I took a bottle of advil and three boxes worth of sleeping pills, along with the anti depressants I had been taking.Whatever the reason underlying the overdose, excessive amounts of acetaminophen have the potential to be medically dangerous and can result in acute liver failure. Acute liver failure can be fatal ...34 Related Topics Science 34 comments Best Top New Controversial Q&A dblowe Organic Chemistry | Drug Discovery • 8 yr. ago No. The liver damage only occurs when the normal metabolic pathways for acetaminophen are overloaded or somehow damaged.Acetaminophen is found in combination with opioids (e.g. Percocet) and as part of many over the counter cold medications (e.g. Sudafed); can lead to accidental overdose. Signs and Symptoms Stage I – 0-24 hours: anorexia, nausea, vomiting, diaphoresis, lethargy, malaise, pallor; may also be asymptomatic, especially early.The diagnosis of acetaminophen toxicity is based on serum levels of the drug, even if there are no symptoms. Other laboratory studies needed include liver function tests (LFTs) and coagulation profile … ….

Tylenol doesn’t kill immediately, it takes about 36-48 hours so people think they’re in the clear when they wake up. You are missing a crucial window before she dies of liver failure. 7-8 grams is most certainly enough to cause serious injury or death depending on weight. Go to the hospital. You combine medications. If your child has various cold symptoms, your instinct might be to combine acetaminophen with an over-the-counter remedy. If the remedy contains acetaminophen, this can result in a dangerously high dose. Also, cough and cold medicines should be avoided in children younger than age 6 due to possibly …Symptoms of an overdose can include: loss of appetite nausea vomiting pain in the abdomen or belly, especially in the upper right side Was this helpful? Also seek emergency care if you notice...Signs of toxicity from acetaminophen may develop within 1–4 hours of ingestion. These cats will experience a progressive depression, and they may develop rapid breathing. They may experience abdominal pain and nausea, causing drooling. Their mucus membranes, for example, the gums or the tissue surrounding the globe of the eye, may develop a ...However, let's assume you're taking the max dose of Paracetamol and a strong cold and flu (same dose of paracetamol) because you don't realise. That's 2000mg every 4 hours, 8000mg a day. The 23 pill overdose is 11,500mg. If you do that for a few days, it's likely it'll build up in your system you'll achieve paracetamol toxicity.Symptoms include abdominal pain, diarrhea, jaundice, nausea, vomiting, and convulsions. The first step for a suspected acetaminophen overdose should be to call ...Safe use. Acetaminophen is safe and effective when used as directed. The total amount of acetaminophen taken in a day from all sources should not exceed 4,000 mg for: adults. children aged 12 years and older. Over 24 hours, this equals: 8 extra strength pills (each pill contains 500 mg) 12 regular strength pills (each pill contains 325 mg) The ...That's the defining characteristic of a tylenol OD--it is completely asymptomatic in its initial stages. If you're taking >4,000 mg of acetaminophen a day, you risk irreversible liver damage. The first symptoms will be feeling tired and achy, like you have the flu. If your child has symptoms of an acetaminophen overdose after taking the medication, or you suspect an accidental overdose, seek emergency medical treatment immediately. Call local emergency (911) or your local poison control center, which can be reached through the national toll-free poison help hotline (1-800-222-1222).Emergency room doctors are trained to recognize the symptoms of what is now a common overdose in children. Most acetaminophen overdoses are detected early, and treated with an effective antidote ... Acetaminophen overdose symptoms reddit, 15‏/02‏/2018 ... Emma Sturgeon's Adderall overdose photos went viral on Reddit. Here, she shares her overdose story and how she got clean from uppers and ..., If taken in recommended doses, there is no risk of poisoning from acetaminophen. In fact, to prevent accidental overdose, the maker of Extra-Strength Tylenol brand acetaminophen has reduced the ... , 15‏/02‏/2018 ... Emma Sturgeon's Adderall overdose photos went viral on Reddit. Here, she shares her overdose story and how she got clean from uppers and ..., Valproate is a commonly used antiepileptic drug for the treatment of generalized and partial seizures. It is safe for use in both adults and children more than three years of age. It came to the market in 1978, and since then its use has broadened to include the treatment of bipolar and schizoaffective disorders, neuropathic pain, and prophylactic …, Acetaminophen poisoning is rarely fatal (0.1%), even when overdoses are intentional. However, in the rare cases where the overdose is too much for the body, death is NOT caused by the medication itself, but by acute liver failure after the fact. A Tylenol overdose might put you to sleep, but you will probably wake back up one last time. , Study Group identified acetaminophen toxicity as the cause of ALF in 20% of cases.17 Subsequent studies reported acetaminophen overdose to be the most common cause of ALF, accounting for 39% to 42% of all cases, with suicidal intent in 27% to 44% and unintentional overdose in 48% to 61%.3,18,19 Of the patients with acetaminophen …, Unless you have a serious liver condition, most liver toxicity has almost no symptoms. You have to detect it with lab tests, and in healthy people it corrects itself as soon as whatever was causing the problem is cleared away. , Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J. 1979 Nov 03;2(6198):1097-100. Chiew AL, Isbister GK, Kirby KA, Page CB, Chan BSH, Buckley NA. Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2)., A. History Part I: Pattern Recognition: Acute acetaminophen poisoning develops in four stages post-ingestion. In the initial 24 hours, patients may be asymptomatic or have non-specific symptoms ..., Acetaminophen Poisoning. Acetaminophen, a common ingredient in many prescription and non-prescription drugs, is safe in normal doses, but severe overdose can cause liver failure and death. People sometimes ingest too many products that contain acetaminophen and poison themselves. Depending on the amount of acetaminophen in the blood, …, Taking too much acetaminophen can be deadly because it can lead to hepatotoxicity (liver toxicity). Because Tylenol is available over the counter, acetaminophen overdose is one of the most common types of overdose around the world today. The liver is responsible for converting and clearing many chemicals from the body, including drugs like ..., But as a constant stream of mixed medication. That's simply stupid. Short-term studies of therapeutic doses of acetaminophen in abstinent alcoholics have not demonstrated hepatotoxicity. So there's that. Many patients with non-intentional acetaminophen overdose report short-term fasting and/or poor nutritional status immediately preceding the ..., Diagnosis. Treatment. Acetaminophen poisoning can cause gastroenteritis within hours and hepatotoxicity 1 to 3 days after ingestion. Severity of hepatotoxicity after a single acute overdose is predicted by serum acetaminophen levels. Treatment is with N - acetylcysteine to prevent or minimize hepatotoxicity., In acute ingestion, a formal definition for massive overdose has yet to be operationally defined. Depending on the study, massive cumulative ingestion ranges have been defined as >30g to >50 g and massive APAP concentrations have been defined as >250 mcg/ml to >500 mcg/ml at 4 hours post ingestion. Regardless, massive overdose …, Acetaminophen and codeine overdose. Acetaminophen (Tylenol) and codeine is a prescription pain medicine. It is an opioid pain reliever used only for pain that is severe and is not helped by other types of painkillers. Acetaminophen and codeine overdose occurs when someone takes more than the normal or recommended amount …, Nausea or vomiting. Abdominal pain. Diarrhea. Loss of appetite. Jaundice. Mood changes. “Some people may not have any symptoms or only very mild ones,” notes Grassi. More serious symptoms include seizures or a loss of consciousness. Symptoms can develop slowly and may take up to 12 hours to come on., Alcohol can cloud judgment and impair impulse control, making overdose more likely. It can also interact adversely with medications like acetaminophen and can harm the liver, perhaps making the..., In general the recommended maximum daily dose for healthy adults is 4 grams. Higher doses lead to increasing risk of toxicity. In adults, single doses above 10 grams or 200 mg/kg of bodyweight, whichever is lower, have a reasonable likelihood of causing toxicity. [3] [4] Toxicity can also occur when multiple smaller doses within 24 hours ..., Soon after taking an overdose of acetaminophen, the person may have no symptoms from taking a toxic amount. They may remain symptom free for up to 24 hours after taking a toxic overdose of acetaminophen. After this initial period, the following symptoms are common in acetaminophen (Tylenol) poisoning: Nausea. Vomiting., Signs of toxicity from acetaminophen may develop within 1–4 hours of ingestion. These cats will experience a progressive depression, and they may develop rapid breathing. They may experience abdominal pain and nausea, causing drooling. Their mucus membranes, for example, the gums or the tissue surrounding the globe of the eye, may develop a ..., hives, itching, or skin rash. increase in heart rate. increased thirst. increased volume of pale, dilute urine. lightheadedness. muscle pain or cramps. nausea. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. rapid breathing., Aug 23, 2007 · Here in Colorado, the Rocky Mountain Poison Center received 835 calls in 2006 for acetaminophen overdose in children 5 and under, according to Mary Hilko, public education coordinator. In the U.S ... , Acetaminophen (APAP) toxicity is among the most common medication-related overdoses and accounts for nearly half of all liver transplantations in the United States . Poisoning can occur through single or repeated ingestions. With therapeutic dosing, APAP is metabolized primarily via glucuronidation and sulfation to nontoxic …, Nation Jul 10, 2023 2:47 PM EDT. CAMBRIDGE, Mass. (AP) — The suspect in the 1982 Tylenol poisonings that killed seven people in the Chicago area and triggered a nationwide scare has died, police ..., This case describes a patient with massive naproxen ingestion whose peak naproxen serum concentration of 1,580 mg/L at 90 min is, to our knowledge, the highest ever reported. One previous case report of naproxen overdose (25 g) described only minor symptoms of nausea and stomach upset with a serum level of 414 mg/L [ 3 ]., Acetaminophen. Acetaminophen is an active ingredient in hundreds of over-the-counter (OTC) and prescription medicines. It relieves pain and fever. Acetaminophen can also be combined with other ..., Acetaminophen Poisoning. Acetaminophen, a common ingredient in many prescription and non-prescription drugs, is safe in normal doses, but severe overdose can cause liver failure and death. People sometimes ingest too many products that contain acetaminophen and poison themselves. Depending on the amount of acetaminophen in the blood, …, No. The liver damage only occurs when the normal metabolic pathways for acetaminophen are overloaded or somehow damaged. The drug can be cleared by …, Symptoms of liver damage include: yellowing of your skin or the whites of your eyes (jaundice) pain in the upper right area of your abdomen. nausea or vomiting. loss of appetite. fatigue. sweating ..., Aug 24, 2023 · "In general, the most acetaminophen adults can safely take is 4,000 milligrams or 4 grams in a 24-hour period,” says Grassi. To help keep track of how much you’re taking, set a reminder in your phone or on your voice assistant. Symptoms of an acetaminophen overdose. About one-third of acetaminophen overdoses in the U.S. are accidental. , Symptoms of toxicity following overdose of acetaminophen (APAP), now a common household medication, occur 24 to 48 hours following ingestion. Toxicity is mainly to the liver but, while data has implicated a minor metabolite, the precise mechanism is not known. Toxicity is likely to occur after a minimum ingestion of 140 mg/kg, but the toxic ..., The first symptoms will be feeling tired and achy, like you have the flu. You may also develop pain in the upper right part of your abdomen. Then you'll turn yellow as accumulated bilirubin builds up in your body (your liver normally excretes it as bile). Your stools will turn grey or chalky white as well, since bile colors them brown., Background. APAP toxicity may be caused by a single large overdose or repeated supratherapeutic dosing, rarely by chronic low doses (≤ 3-4 g/day). Severe liver toxicity (peak AST or ALT >1000 IU/L) develops in virtually all patients who ingest doses in excess of 350 mg/kg. Accounts for up to half of all cases of acute liver failure in U.S.