Methocarbamol wiki

Media in category "Methocarbamol". The following 15 files are in this category, out of 15 total. (R)-Methocarbamol.svg 1,228 × 601; 12 KB. MephenesinDerivatives.png 1,795 × 570; 13 KB. Methocarbamol 750 MG Oral Tablet.jpg 840 × 600; 21 KB. Methocarbamol costs (DrugStats).svg 1,024 × 768; 16 KB.

Methocarbamol, sold under the brand name Robaxin among others, is a medication used for short-term musculoskeletal pain. It may be used together with rest, physical therapy, and pain medication. It is less preferred in low back pain. It has limited use for rheumatoid arthritis and cerebral palsy. One type of antispasmodics is used for smooth muscle relaxation, especially in tubular organs of the gastrointestinal tract. The effect is to prevent spasms of the stomach, intestine or urinary bladder . Both dicyclomine and hyoscyamine are antispasmodic due to their anticholinergic action. Both of these drugs have general side effects and can ...- Align: Centre - Border: Yes - Font: Arial Black - Ink Colour: Red - Spare Ink Pad: VioletIn a head-to-head trial between methocarbamol and cyclobenzaprine, there was no significant difference in muscle spasms or tenderness. However, patients experienced slightly better improvements …Deje de usar methocarbamol y llame a su médico de inmediato si usted tiene: sensación de desvanecimiento, como que se va a desmayar; latidos cardíacos lentos; fiebre, escalofríos, síntomas de la gripe; convulsiones; o. ictericia (color amarillo de la piel u ojos). Efectos secundarios comunes pueden incluir:methocarbamol following intravenous (Table 1.1) and oral (Table 1.2) administrations are expressed as the mean, median, and range at the 24- and 48-hour collection points. Table 1.1 Plasma methocarbamol mean, median, minimum and maximum values following intravenous administration of 15 mg/kg of methocarbamol to 20 horses Time (hours)Nebenwirkungen. Methocarbamol ist ein zentral wirkendes Skelettmuskelrelaxans, das erhebliche unerwünschte Wirkungen hat, insbesondere auf das zentrale Nervensystem. Mögliche Nebenwirkungen sind: Schläfrigkeit. verschwommenes Sehen. Kopfschmerzen. Übelkeit.Dr. Alan Ali answered. Psychiatry 34 years experience. Methocarbamol: Is a central muscle relaxant to treat spasms. It has abuse profile similar to, but weaker than, Lorazepam ( ativan ). At high doses, it can produce dysphoria. Created for people with ongoing healthcare needs but benefits everyone.

All Activity; Home ; Forums ; ASBMR Task Force for Clinical Algorithms on Fracture Risk ; ASBMR Task Force on Clinical Algorithms for Fracture RiskSep 19, 2023 · How Ortoton works. The mechanism of action of methocarbamol is thought to be dependant on its central nervous system depressant activity. This action may be mediated through blocking spinal polysynaptic reflexes, decreasing nerve transmission in spinal and supraspinal polysynaptic pathways, and prolonging the refractory period of muscle cells. Secobarbital (as the sodium salt, originally marketed by Eli Lilly and Company for the treatment of insomnia, and subsequently by other companies as described below, under the brand name Seconal) is a short-acting barbiturate derivative drug that was patented in 1934 in the United States. It possesses anaesthetic, anticonvulsant, anxiolytic, sedative, and hypnotic properties.Psychopedia is a collaborative wiki about the Psychonauts series that anyone can edit. It is the successor to Old Psychopedia. It was created in September 2006 and currently has 976 articles. Psychonauts follows Razputin, a young boy gifted with psychic abilities who runs away from the circus to try to sneak into a psychic summer camp. 1. meltingspace • 10 yr. ago. Robaxin (or methocarbamol) is a skeletal muscle relaxer and can cause CNS depressant effects. "The goal of muscle relaxants is to normalize muscle excitability, decrease pain, and improve motor function. They exert their pharmacologic effect centrally at the level of the spinal cord, the brainstem, or the cerebrum.

Metaxalone may cause serious side effects. Stop using metaxalone and call your doctor at once if you have: weak or shallow breathing; a light-headed feeling, like you might pass out; pale or yellowed skin, dark colored urine, fever, confusion or weakness; or. upper stomach pain, loss of appetite, jaundice (yellowing of the skin or eyes).Methocarbamol Tablets are contraindicated in patients hypersensitive to methocarbamol or to any of the tablet components. Warnings Precautions. Since methocarbamol may possess a general CNS depressant effect, patients receiving Methocarbamol Tablets should be cautioned about combined effects with alcohol and other CNS depressants.robaxin ® -750 (methocarbamol): 750 mg - Adults: Initial dosage: 2 tablets q.i.d. Maintenance dosage: 1 tablet q.4h. or 2 tablets t.i.d. Six grams a day are recommended for the first 48 to 72 hours of treatment. (For severe conditions 8 grams a day may be administered.) Thereafter, the dosage can usually be reduced to approximately 4 grams a ...by Gina Trapani by Gina Trapani A wiki is an editable web site, where any number of pages can be added and the text of those pages edited right inside your web browser. Wiki's are perfect for a team of multiple people collaboratively editin...English: Skeletal formula of methocarbamol (brand name Robaxin) — a skeletal muscle relaxant (antispasmodic). Created with ChemDoodle 7.0.2 and Adobe Illustrator CC 2015 . ତାରିଖ

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Sep 7, 2023 · No, methocarbamol is not scheduled by the DEA in any category. Metaxolone (Skelaxin) isn't either. Carisoprodol (Soma) is the only similar agent that is currently scheduled (Sched IV).Maine PharmD - Align: Centre - Border: Yes - Font: Arial Black - Ink Colour: Red - Spare Ink Pad: VioletMethocarbamol ist ein Arzneistoff, der bei Verspannungen und Spasmen der Skelettmuskulatur als Spasmolytikum eingesetzt wird. Er gehört zur Gruppe der zentral wirksamen Muskelrelaxanzien (Myotonolytika). [2] Der genaue Wirkmechanismus des Arzneistoffs ist noch ungeklärt.We currently have 1,576 articles about the country-life RPG developed by ConcernedApe . Stardew Valley is an open-ended country-life RPG! You’ve inherited your grandfather’s old farm plot in Stardew Valley. Armed with hand-me-down tools and a few coins, you set out to begin your new life. Can you learn to live off the land and turn these ...

So let’s look at nine popular muscle relaxants, including how well they work and their side effects. 1. Methocarbamol. Methocarbamol (Robaxin) is a well-studied medication that treats back pain. Compared to other options, it’s inexpensive and less likely to make you sleepy (sedated).This study was conducted to characterize the muscle relaxant activity of methocarbamol enantiomers. The rotarod test was used to compare the muscle relaxant activity of racemic methocarbamol and pure enantiomers after intraperitoneal administration of the enantiomers to mice. The results show that (+)-R-methocarbamol has higher muscle relaxant ...Robaxin (methocarbamol) is a muscle relaxant used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. What Is Baclofen? Baclofen is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Molecular Formula CHNO Average mass 241.240 Da Monoisotopic mass 241.095016 Da ChemSpider ID 3964 More details: Featured data source Names Properties Searches Spectra Vendors Articles More Names and Synonyms Database ID (s) Validated by Experts, Validated by Users, Non-Validated, Removed by UsersDOI: 10.1097/MJT.0000000000000364. There is interest in the use of methocarbamol as an adjunctive agent for pain control after traumatic injury. The primary objective of this study was to determine the effect of methocarbamol on pain measurements after acute injury. This was a retrospective, matched cohort study conducted at an academic medical ...View methocarbamol information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding and contra-indications. Methocarbamol wiki. Guaranteed Quality without prescription. Methocarbamol other drugs in same class. Low prices.Pain is sharp or burning. Radiates to trapzezial and periscapular areas or down arm. Numbness/weakness in myotomal distribution. Headache may occur if upper cervical roots are involved. Symptoms aggravated by neck hyperextension (esp when head is toward affected extremity) Gradual onset of shocklike sensations spreading down spine to extremities.How to say Metica in English? Pronunciation of Metica with 1 audio pronunciation and more for Metica.

Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms. Under the trade name Robaxin, it is marketed by Actient Pharmaceuticals in the United States and Pfizer in Canada. The mechanism of action of methocarbamol is currently unknown, but may involve the inhibition of carboni

Methocarbamol Tablets USP, 500 mg are light orange colored, round, film-coated tablets, engraved with 'B134' on one side and scored on the other side. They are supplied as follows: Bottles of 40 NDC 72789-110-40. Store at controlled room temperature, between 20°C and 25°C (68°F and 77°F). Dispense in tight container.Media in category "Methocarbamol" The following 15 files are in this category, out of 15 total. (R)-Methocarbamol.svg 1,228 × 601; 12 KB. MephenesinDerivatives.png 1,795 × 570; 13 KB. Methocarbamol 750 MG Oral Tablet.jpg 840 × 600; 21 KB. ... In Wikipedia. العربية ...Methocarbamol does not directly relax tense skeletal muscles in man. 500 mg - Initial dosage, 3 tablets q.i.d.; maintenance dosage, 2 tablets q.i.d. 750 mg - Initial dosage, 2 tablets q.i.d.; maintenance dosage, 1 tablet q.4h. or 2 tablets t.i.d. Six grams a day are recommended for the first 48 to 72 hours of treatment. (For severe conditions 8 ...Location. Inside of a heart-shaped box. Apr 25, 2011. #3. Many people claim they don't get any euphoria with these. I am a major fan of soma at around the 700mg range. With these I get complete back pain relief (with a little hydrocodone) at 750mg. The euphoria is found by getting a back rub or laying still for a long period of time.Pregabalin (Lyrica) is an anticonvulsant drug. It is formulated in the form of capsule and solution for oral administration. Pregabalin Pregabalin (Lyrica) generic Lyrica (150 mg) is an anticonvulsant used as an additional treatment of partial seizures. It is also effective against nerve-related.Read this chapter of Davis's Drug Guide for Rehabilitation Professionals online now, exclusively on F.A. Davis PT Collection. F.A. Davis PT Collection is a subscription-based resource from McGraw Hill that features trusted content from the best minds in PT.Methocarbamol is a centrally acting muscle relaxant. Its muscle relaxing action is the result of the inhibition of polysynaptic reflexes in the spinal marrow and subcortical centres. Methocarbamol, at the therapeutic dose, does not affect the physiological tonus and contractility of the skeletal muscles as well as the motility of non-striated ...It is known as 3- (2-methoxyphenoxy)-1,2-propanediol 1-carbamate; 3- (o-methoxyphenoxy)-2-hydroxypropyl 1 -carbarnate; 2-hydroxy-3- (o-methoxyphenoxy)propyl 1-carbarnate, or guaifenesin carbamate. The term methocarbamol refers to the racemate unless otherwise specified. It appears as colorless (white) crystals or powder; odorless, or with a ...

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Methocarbamol is a centrally acting muscle relaxant. Its muscle relaxing action is the result of the inhibition of polysynaptic reflexes in the spinal marrow and subcortical centres. Methocarbamol, at the therapeutic dose, does not affect the physiological tonus and contractility of the skeletal muscles as well as the motility of non-striated ...Methocarbamol Tablets, USP, 500 mg and 750 mg, a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties. The chemical name of methocarbamol is 3-(2-methoxyphenoxy)-1, 2-propanediol 1-carbamate and has the empirical formula C 11 H 15 NO 5. Its molecular weight is ...So let’s look at nine popular muscle relaxants, including how well they work and their side effects. 1. Methocarbamol. Methocarbamol (Robaxin) is a well-studied medication that treats back pain. Compared to other options, it’s inexpensive and less likely to make you sleepy (sedated).Nov 14, 2022 · Methocarbamol is a medication used in the management and treatment of acute musculoskeletal pain. It is in the skeletal muscle relaxant class of medications. This activity reviews the indications, mechanism of action, and contraindications for methocarbamol as an option in the multimodal treatment o … What is the half life of methocarbamol? Wiki User. ∙ 2011-03-14 15:15:34. Add an answer. Want this question answered? Be notified when an answer is posted. 📣 Request Answer. Study guides.Can you get high from methocarbamol 50 0mg. According to the concepts of cognitive behavioral can you get high from methocarbamol 50 0mg therapy, participating in the is methocarbamol habit forming season. Anxiety First and foremost, anyone who wants to trim their home with holiday wreaths, trees and more may sidestep the stress of rushed preparations by decorating well in advance.Generic Name Pregabalin DrugBank Accession Number DB00230 Background. Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. 13 It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. 20 Although as per the FDA Label the mechanism of action has not been definitively defined, there is evidence ...Each mL contains: methocarbamol, USP 100 mg, polyethylene glycol 300, NF 0.5 mL, Water for Injection, USP q.s. The pH is adjusted, when necessary, with hydrochloric acid and/or sodium hydroxide. The chemical name of methocarbamol is 3‑(2‑methoxyphenoxy)‑1,2-propanediol 1‑carbamate and has the empirical formula of C 11 H 15 NO 5. Its ... ….

Secobarbital (as the sodium salt, originally marketed by Eli Lilly and Company for the treatment of insomnia, and subsequently by other companies as described below, under the brand name Seconal) is a short-acting barbiturate derivative drug that was patented in 1934 in the United States. It possesses anaesthetic, anticonvulsant, anxiolytic, sedative, and …Using that same formula, M=moles/V, we cansee that moles=MV. In the first solution we have (20M) (0.750L) = 15 moles. In the second, (60M) (0.250L) = 15 moles, so we have a total of 30 moles in ...Introduction. Metoprolol is a cardioselective beta-blocker that is used mainly in the treatment of arterial hypertension (Hansson et al., 1999), heart failure (MERIT-HF Study Group, 1999), and myocardial infarction (Chen et al., 2005).Intestinal absorption of metoprolol is rapid and almost complete; however, due to an extensive first pass metabolism (Regardh and Johnsson, 1980), the ...What muscle relaxant is better cyclobenzaprine or methocarbamol? Wiki User. ∙ 2012-12-03 03:44:39. Add an answer. Want this question answered? Be notified when an answer is posted.Methocarbamol Tablets are contraindicated in patients hypersensitive to methocarbamol or to any of the tablet components. Warnings Precautions. Since methocarbamol may possess a general CNS depressant effect, patients receiving Methocarbamol Tablets should be cautioned about combined effects with alcohol and other CNS depressants.Name: Laura Simmonds. July 16, 2023 Newer Post Caroline CrossGeneric Name Pregabalin DrugBank Accession Number DB00230 Background. Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. 13 It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. 20 Although as per the FDA Label the mechanism of action has …Methocarbamol User Reviews & Ratings. Brand names: Robaxin, Carbacot. Methocarbamol has an average rating of 6.2 out of 10 from a total of 288 reviews on Drugs.com. 51% of reviewers reported a positive experience, while 30% reported a negative experience. Condition.Learn what a wiki is, how it's different from a blog, and how to make one for your business. Trusted by business builders worldwide, the HubSpot Blogs are your number-one source for education and inspiration. Resources and ideas to put mode...Methocarbamol is a muscle relaxant used to treat acute, painful musculoskeletal spasms in a variety of musculoskeletal conditions. However, there is limited and inconsistent published research on the medication's efficacy and safety in treating musculoskeletal conditions, primarily neck and back pain. Methocarbamol wiki, Mephenesin ( INN) is a centrally acting muscle relaxant. It can be used as an antidote for strychnine poisoning. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a ..., So let’s look at nine popular muscle relaxants, including how well they work and their side effects. 1. Methocarbamol. Methocarbamol (Robaxin) is a well-studied medication that treats back pain. Compared to other options, it’s inexpensive and less likely to make you sleepy (sedated)., December 6, 2021, how to get methocarbamol in the us methocarbamol acetaminophen codeine to holders of the vaccine. Individuals should not get the Pfizer-BioNTech COVID-19 Vaccine for individuals at least a 4-fold increase in anti-OspA IgG antibody titers declined thereafter across all serotypes (ST1 - ST6) at one month apart. ..., cold, clammy skin. trouble walking or talking. feeling faint, dizzy, or confused. unresponsiveness. Many fatal overdoses thought to be from heroin have actually been from fentanyl. Even a small ..., Muscle relaxants - cyclobenzaprine, methocarbamol, diazepam; Refer to pain specialist for multidisciplinary approach; Pain specialists can offer (discussion with patient in ED): Injections - trigger point, epidural steroid injections, facet injections, medial branch blocks, joint steroid injections; Radiofrequency ablations; Spinal implants, Get the most recent info and news about AltexSoft on HackerNoon, where 10k+ technologists publish stories for 4M+ monthly readers. #86 Company Ranking on HackerNoon Get the most recent info and news about AltexSoft on HackerNoon, where 10k+..., 1. What Methocarbamol is and what it is used for Methocarbamol tablets contain the active substance methocarbamol. This is an active substance for treatment of muscle spasms. Methocarbamol is used for the symptomatic treatment of painful muscle spasms, especially in the lower back (lumbago). 2. What you need to know before you take Methocarbamol, Prolonged ventricular repolarization → increased risk of ventricular arrhythmias. Males >440-450 ms. Females >500 ms. Rule of thumb: Normal QT interval is less than half of preceding RR interval. QT interval is from the beginning of the Q wave to the end of the T wave., DESCRIPTION. robaxin®/robaxin®- 750 (methocarbamol tablets, USP), a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties.. The chemical name of methocarbamol is 3-(2-methoxyphenoxy) -1,2propanediol 1-carbamate and has the empirical formula C 11 H 15 NO 5.Its molecular weight is 241.24., Nebenwirkungen. Methocarbamol ist ein zentral wirkendes Skelettmuskelrelaxans, das erhebliche unerwünschte Wirkungen hat, insbesondere auf das zentrale Nervensystem. Mögliche Nebenwirkungen sind: Schläfrigkeit. verschwommenes Sehen. …, C₁₁H₁₅NO₅. ChEBI. 77498. Massa. 241,095023 unidade de massa atómica. [ edite no Wikidata] O metocarbamol, vendido sob a marca Robaxin, entre outras, é um medicamento usado para tratar dores musculoesqueléticas de curto prazo. [ 1][ 2] Pode ser usado para repouso, fisioterapia e com analgésicos. [ 1][ 3][ 4] É menos indicado para ... , robaxin ® -750 (methocarbamol): 750 mg - Adults: Initial dosage: 2 tablets q.i.d. Maintenance dosage: 1 tablet q.4h. or 2 tablets t.i.d. Six grams a day are recommended for the first 48 to 72 hours of treatment. (For severe conditions 8 grams a day may be administered.) Thereafter, the dosage can usually be reduced to approximately 4 grams a ..., Los consumidores pueden ahorrar dinero visitando CuidadoDeSalud. The fact that this pandemic generic methocarbamol prices to an end. Administration who methocarbamol 75 0mg per tablet are committed to addressing COVID with the power to change that. Good morning and thank you all for joining us today., Methocarbamol should be used with caution in patients with impaired renal and/or hepatic function. Methocarbamol tablets contain lactose . Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine. Methocarbamol tablets contain soya lecithin, Secobarbital (as the sodium salt, originally marketed by Eli Lilly and Company for the treatment of insomnia, and subsequently by other companies as described below, under the brand name Seconal) is a short-acting barbiturate derivative drug that was patented in 1934 in the United States. It possesses anaesthetic, anticonvulsant, anxiolytic, sedative, and hypnotic properties., Welcome to the Warriors Wiki! We are a wiki based on Erin Hunter's Warriors book series that anyone can edit. Since our founding on 21 June 2006, we have 4,810 articles, 1,733,124 edits, and currently 142 active editors. Our goal is …, More answers. Yes. Methamphetamine is a DEA Schedule 2 drug, meaning that it has an FDA medically approved use, but has a high potential for abuse and dependence. It is legal only if used in the ..., Find information on Methocarbamol (Robaxin) in Davis's Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF., Methocarbamol Tablets USP, 500 mg are light orange colored, round, film-coated tablets, engraved with 'B134' on one side and scored on the other side. They are supplied as follows: Bottles of 40 NDC 72789-110-40. Store at controlled room temperature, between 20°C and 25°C (68°F and 77°F). Dispense in tight container., A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therapeutic groups: neuromuscular blockers and spasmolytics. Neuromuscular blockers act by interfering with ..., Methocarbamol Tablets USP, a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties. The chemical name of methocarbamol is 3 - (2-methoxyphenoxy) -1, 2- propanediol 1-carbamate and has the empirical formula C 11 H 15 NO 5. Its molecular weight is 241.24., What is the half life of methocarbamol? Wiki User. ∙ 2011-03-14 15:15:34. Add an answer. Want this question answered? Be notified when an answer is posted. 📣 Request Answer. Study guides., Coronavirus Support Network (for Biddenham) 01234 815393 Parish Clerk 07870108315 Bedfordshire Fire & Rescue Service 01234 845000 Bedfordshire Police, Methocarbamol dosage for dogs. Unless your vet has some concerns over how your dog will handle the medication (more on that below), they'll tend to prescribe a minimum of 20 mg per pound of your pet, with more for severe cases (although note that even 30 mg would be considered a "heavy" prescription). This first dose is usually stronger ..., Sep 6, 2023 · What is methocarbam? Methocarbamol is also known as Robaxin. It is a is a central nervous system depressant with sedative and musculoskeletal relaxant properties that is derived from guaifenesin. , About Wikipedia; Contact us; Donate; Contribute Help; Learn to edit; Community portal; Recent changes; Upload file; Languages. Language links are at the top of the page across from the title. Search. Search. Create account; Log in;, Methocarbamol is a skeletal muscle relaxant prescribed by veterinarians to treat and alleviate inflammatory pain in horses. This musculoskeletal system inflammation can be the result of myositis, neurological issues, muscle or ligament strains, and vertebral disc disease. Methocarbamol addresses these issues by reducing muscle spasms within the ..., The Association of City and County Health Officials (NACCHO) for a career in public methocarbamol street price health agencies to enhance capacity and performance. Mark your calendars for September 9 at 3:00 pm (EDT), presenters will share findings from a recent report and discuss four cases that illustrate opportunities for the 2021 Strategic ..., COVID-19; the collaboration between BioNTech and Pfizer to develop prophylactic vaccines for how much does methocarbamol cost on the street children in high- and non-high income countries. RNA-based influenza vaccine as a 2-dose series for prevention of invasive disease and pneumonia caused by genetic mutations or acquired after birth., Executive Vice can you take methocarbamol and ibuprofen together President Stacey Hughes. The rule means providers will have to be any time for dilly-dallying. She conducted pain research at UW for over 30 years and played a key direction the rule gave to the methocarbamol., Methocarbamol is a medication used to treat muscle pain and stiffness. It is also used to treat other conditions such as arthritis, bursitis, and tendinitis. Methocarbamol is a muscle relaxant that works by blocking pain signals from the brain to the muscles. It is available as an oral tablet, an oral suspension, and an injectable solution., Systematic (IUPAC) name 2 hydroxy 3 (2 methoxyphenoxy)propyl carbamate Clinical data AHFS/Drugs.com, The review of medicines containing methocarbamol and paracetamol was initiated on 29 May 2019 at the request of Germany under Article 31 of Directive 2001/83/EC. The review was carried out by the Committee for Medicinal Products for Human Use ( CHMP ), responsible for questions concerning medicines for human use, which has adopted the Agency ...